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EHHADH
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. Liver and kidney. Strongly expressed in the terminal segments of the proximal tubule. Lower amounts seen in the brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation |
| Chromosomal Location of mouse Ortholog: 16|16 B1 |
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Cellular Component:
cytosol; peroxisome
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Molecular Function:
3-hydroxyacyl-CoA dehydrogenase activity; catalytic activity; delta(3)-delta(2)-enoyl-CoA isomerase activity; enoyl-CoA hydratase activity; enzyme binding; intramolecular oxidoreductase activity, transposing C=C bonds; isomerase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; lyase activity; NAD+ binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Biological Process:
acyl-CoA metabolic process; fatty acid beta-oxidation; fatty acid metabolic process; lipid metabolic process; metabolic process
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Reference #:
Q9DBM2
(UniProtKB)
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Alt. Names/Synonyms: 1300002P22Rik; 3-hydroxyacyl-CoA dehydrogenase; ECHP; Ehhadh; Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; HD; L-bifunctional enzyme; L-P; L-PBE; L-peroxisomal bifunctional enzyme; L-specific multifunctional beta-oxdiation protein; LBFP; LBP; MFE1; MFP; MFP-1; MFP1; Multifunctional enzyme 1; Multifunctional protein 1; PBE; PBFE; Peroxisomal bifunctional enzyme
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Gene Symbols: Ehhadh
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Molecular weight:
78,301 Da
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Basal Isoelectric point:
9.22
Predict pI for various phosphorylation states
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