KIFAP3 Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1|1 H2.1
Cellular Component:  axoneme; centrosome; ciliary basal body; condensed nuclear chromosome; endoplasmic reticulum; Golgi apparatus; kinesin complex; kinesin II complex; microtubule cytoskeleton; periciliary membrane compartment; photoreceptor connecting cilium; photoreceptor inner segment
Molecular Function:  intraciliary transport particle B binding; kinesin binding; protein binding; protein phosphatase binding
Biological Process:  microtubule-based process; negative regulation of apoptotic process; negative regulation of cell proliferation; positive regulation of calcium-dependent cell-cell adhesion; protein localization
Reference #:  P70188 (UniProtKB)
Alt. Names/Synonyms: KAP-3; KAP3; KIFA3; Kifap3; Kinesin-associated protein 3; OTTMUSP00000019806; SMAP; Smg GDS
Gene Symbols: Kifap3
Molecular weight: 91,291 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene