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14-3-3 sigma
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression. Belongs to the 14-3-3 family. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 4 D2.3|4 66.25 cM |
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Cellular Component:
cytoplasm; cytosol; extracellular region; nucleus
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Molecular Function:
identical protein binding; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding
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Biological Process:
establishment of skin barrier; intrinsic apoptotic signaling pathway in response to DNA damage; keratinization; keratinocyte development; keratinocyte differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of keratinocyte proliferation; positive regulation of cell growth; positive regulation of epidermal cell differentiation; positive regulation of protein export from nucleus; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of epidermal cell division; release of cytochrome c from mitochondria; skin development
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Reference #:
O70456
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3; 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3 sigma protein; 1433S; Er; Mkrn3; Mme1; OTTMUSP00000011953; Sfn; stratifin; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; Ywh; Ywhas
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Gene Symbols: Sfn
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Molecular weight:
27,706 Da
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Basal Isoelectric point:
4.72
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Hippo Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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