14-3-3 sigma Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression. Belongs to the 14-3-3 family. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 4 D2.3|4 66.25 cM
Cellular Component:  cytoplasm; cytosol; extracellular region; nucleus
Molecular Function:  identical protein binding; phosphoprotein binding; protein binding; protein kinase binding
Biological Process:  establishment of skin barrier; intrinsic apoptotic signaling pathway in response to DNA damage; keratinization; keratinocyte development; keratinocyte differentiation; keratinocyte proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of keratinocyte proliferation; negative regulation of stem cell proliferation; positive regulation of cell growth; positive regulation of epidermal cell differentiation; positive regulation of protein export from nucleus; protein localization; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of epidermal cell division; release of cytochrome c from mitochondria; signal transduction; skin development; stem cell proliferation
Reference #:  O70456 (UniProtKB)
Alt. Names/Synonyms: 14-3-3; 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3 sigma protein; 1433S; Er; Mkrn3; Mme1; OTTMUSP00000011953; Sfn; stratifin; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; Ywh; Ywhas
Gene Symbols: Sfn
Molecular weight: 27,706 Da
Basal Isoelectric point: 4.72  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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14-3-3 sigma

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein