requiem Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway. Belongs to the requiem/DPF family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 19 A|19 4.34 cM
Cellular Component:  centrosome; cytoplasm; cytosol; histone acetyltransferase complex; intracellular membrane-bounded organelle; nBAF complex; nuclear chromatin; nucleoplasm; nucleus
Molecular Function:  H3K9me3 modified histone binding; histone acetyltransferase activity; histone binding; lysine-acetylated histone binding; metal ion binding; nucleic acid binding
Biological Process:  apoptotic process; chromatin organization; negative regulation of myeloid progenitor cell differentiation; negative regulation of transcription, DNA-templated; nervous system development; positive regulation of transcription by RNA polymerase II
Reference #:  Q61103 (UniProtKB)
Alt. Names/Synonyms: 2210010M07Rik; Apoptosis response zinc finger protein; BAF45D; BRG1-associated factor 45D; D4, zinc and double PHD fingers family 2; Dpf2; neuro-d4/requiem; Protein requiem; Req; REQU; requiem; ubi-d4; Ubid4; Zinc finger protein ubi-d4
Gene Symbols: Dpf2
Molecular weight: 44,230 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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requiem

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene