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requiem
Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway. Belongs to the requiem/DPF family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; C2H2-type zinc finger protein |
| Chromosomal Location of mouse Ortholog: 19 A|19 4.34 cM |
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Cellular Component:
centrosome; chromatin; cytoplasm; cytosol; intracellular membrane-bounded organelle; nBAF complex; nucleoplasm; nucleus; SWI/SNF complex; SWI/SNF superfamily-type complex
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Molecular Function:
H3K9me3 modified histone binding; lysine-acetylated histone binding; metal ion binding
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Biological Process:
apoptotic process; chromatin organization; chromatin remodeling; negative regulation of myeloid progenitor cell differentiation; nervous system development; positive regulation of double-strand break repair; positive regulation of stem cell population maintenance; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of transcription by RNA polymerase II
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Reference #:
Q61103
(UniProtKB)
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Alt. Names/Synonyms: 2210010M07Rik; Apoptosis response zinc finger protein; BAF45D; BRG1-associated factor 45D; D4, zinc and double PHD fingers family 2; Dpf2; neuro-d4/requiem; Protein requiem; Req; REQU; requi; requiem; ubi-d; ubi-d4; Ubid4; Zinc finger protein ubi-d4
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Gene Symbols: Dpf2
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Molecular weight:
44,230 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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