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KHS1
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of human Ortholog: 14q22.1 |
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Cellular Component:
cytoplasm
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Molecular Function:
ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
intracellular signal transduction; MAPK cascade; protein phosphorylation
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Reference #:
Q9Y4K4
(UniProtKB)
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Alt. Names/Synonyms: GCKR; germinal center kinase-related; KHS; KHS1; Kinase homologous to SPS1/STE20; M4K5; MAP4K5; MAPK/ERK kinase kinase kinase 5; MAPKKKK5; MEK kinase kinase 5; MEKKK 5; Mitogen-activated protein kinase kinase kinase kinase 5
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Gene Symbols: MAP4K5
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Molecular weight:
95,024 Da
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Basal Isoelectric point:
7.97
Predict pI for various phosphorylation states
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