KHS1 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. Note: This description may include information from UniProtKB.
Protein type: EC; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of human Ortholog: 14q22.1
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  intracellular signal transduction; MAPK cascade; protein phosphorylation
Reference #:  Q9Y4K4 (UniProtKB)
Alt. Names/Synonyms: GCKR; germinal center kinase-related; KHS; KHS1; Kinase homologous to SPS1/STE20; M4K5; MAP4K5; MAPK/ERK kinase kinase kinase 5; MAPKKKK5; MEK kinase kinase 5; MEKKK 5; Mitogen-activated protein kinase kinase kinase kinase 5
Gene Symbols: MAP4K5
Molecular weight: 95,024 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB