hnRNP M Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA splicing; RNA-binding; Receptor, misc.; Spliceosome
Chromosomal Location of Human Ortholog: 7q13
Cellular Component:  catalytic step 2 spliceosome; cell surface; cytoplasm; nuclear matrix; nucleoplasm; nucleus; paraspeckles; post-mRNA release spliceosomal complex; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  calcium-dependent protein binding; mRNA binding; protein antigen binding; protein binding; protein domain specific binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; cellular response to carcinoembryonic antigen; cellular response to lipopolysaccharide; mRNA splicing, via spliceosome; positive regulation of protein import; positive regulation of protein localization to nucleus; regulation of mRNA stability involved in response to oxidative stress
Reference #:  NP_001103381 (RefSeq)
Alt. Names/Synonyms: Heterogeneous nuclear ribonucleoprotein M; hnRNP M; Hnrnpm; Hnrpm; Hnrpm4; M4 protein; MGC109545
Gene Symbols: Hnrnpm
Molecular weight: 77,630 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene