MARK4 Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT/TAU. Also phosphorylates the microtubule-associated proteins MAP2 and MAP4. Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles. Required for the initiation of axoneme extension during cilium assembly. Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro. Plays a role in cell cycle progression, specifically in the G1/S checkpoint. Reduces neuronal cell survival. Plays a role in energy homeostasis by regulating satiety and metabolic rate. Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway. Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 7|7 A3
Cellular Component:  cell projection; centrosome; ciliary basal body; cytoplasm; cytoskeleton; cytosol; dendrite; gamma-tubulin complex; microtubule cytoskeleton; microtubule organizing center; midbody; neuron projection
Molecular Function:  ATP binding; cytoskeletal anchor activity; gamma-tubulin binding; kinase activity; microtubule binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cell projection organization; cilium organization; intracellular signal transduction; microtubule cytoskeleton organization; nervous system development; phosphorylation; positive regulation of cell cycle; positive regulation of cilium assembly; positive regulation of NLRP3 inflammasome complex assembly; positive regulation of protein localization to centrosome; protein phosphorylation; regulation of centrosome cycle
Reference #:  Q8CIP4 (UniProtKB)
Alt. Names/Synonyms: 2410090P21Rik; C79806; Kiaa1860; MAP/microtubule affinity regulating kinase 4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; Mar; Mark4; MARK4 serine/threonine protein kinase; Markl1
Gene Symbols: Mark4
Molecular weight: 82,644 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene