|
FcER1B
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family. Found on the surface of mast cells and basophils. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 19 A|19 8.46 cM |
|
Cellular Component:
endosome; external side of plasma membrane; Fc-epsilon receptor I complex; membrane; membrane raft; plasma membrane
|
|
Molecular Function:
IgE binding; IgE receptor activity; phosphoprotein binding; protein kinase binding; SH2 domain binding
|
|
Biological Process:
activation of phospholipase C activity; cell surface receptor signaling pathway; immune response; positive regulation of mast cell degranulation; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of release of sequestered calcium ion into cytosol; signal transduction
|
|
Reference #:
P20490
(UniProtKB)
|
|
Alt. Names/Synonyms: Fc epsilon receptor I beta-chain; Fc receptor, IgE, high affinity I, beta polypeptide; Fce1b; Fcer1; Fcer1b; FCERB; FcERI; FcR; FcRB; Fcrbe; Fcrbeta; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; Ms4a1; Ms4a2
|
|
Gene Symbols: Ms4a2
|
|
Molecular weight:
25,963 Da
|
|
Basal Isoelectric point:
4.47
Predict pI for various phosphorylation states
|
