FcER1B High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. Belongs to the MS4A family. Found on the surface of mast cells and basophils. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of mouse Ortholog: 19 A|19 8.46 cM
Cellular Component:  endosome; external side of plasma membrane; Fc-epsilon receptor I complex; integral component of membrane; integral component of plasma membrane; membrane; membrane raft
Molecular Function:  phosphoprotein binding; protein kinase binding; SH2 domain binding
Biological Process:  activation of phospholipase C activity; cell surface receptor signaling pathway; cytokine secretion; Fc-epsilon receptor signaling pathway; immune response; inflammatory response; positive regulation of mast cell degranulation; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of release of sequestered calcium ion into cytosol; signal transduction
Reference #:  P20490 (UniProtKB)
Alt. Names/Synonyms: Fc epsilon receptor I beta-chain; Fc receptor, IgE, high affinity I, beta polypeptide; Fce1b; Fcer1; Fcer1b; FCERB; FcERI; FcR; FcRB; Fcrbe; Fcrbeta; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; Ms4a1; Ms4a2
Gene Symbols: Ms4a2
Molecular weight: 25,963 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene