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NG2
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Detected only in malignant melanoma cells. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 8q24 |
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Cellular Component:
apical plasma membrane; cell projection; cell surface; integral component of membrane; integral component of plasma membrane; lamellipodium membrane; plasma membrane
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Molecular Function:
collagen binding; protein kinase binding
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Biological Process:
activation of MAPK activity; angiogenesis; cell proliferation; glial cell migration; inflammatory response; intracellular signal transduction; negative regulation of neuron projection development; neuron remodeling; positive regulation of peptidyl-tyrosine phosphorylation; response to lithium ion; signal transduction; tissue remodeling; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q00657
(UniProtKB)
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Alt. Names/Synonyms: Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan NG2; Cspg4; HSN tumor-specific antigen; membrane-spanning proteoglycan NG2; Ng2
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Gene Symbols: Cspg4
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Molecular weight:
251,909 Da
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Basal Isoelectric point:
5.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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