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PPP1R3A
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase. Skeletal muscle and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 7q31.1 |
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Cellular Component:
membrane; protein phosphatase type 1 complex
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Molecular Function:
glycogen binding; protein phosphatase 1 binding
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Biological Process:
glycogen metabolic process; regulation of glycogen biosynthetic process
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Disease: Diabetes Mellitus, Noninsulin-dependent
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Reference #:
Q16821
(UniProtKB)
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Alt. Names/Synonyms: glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle; glycogen-associated regulatory subunit of protein phosphatase-1; GM; PP1G; PPP1R3; PPP1R3A; PPR3A; protein phosphatase 1 glycogen- associated regulatory subunit; Protein phosphatase 1 glycogen-associated regulatory subunit; Protein phosphatase 1 regulatory subunit 3A; protein phosphatase 1 regulatory subunit GM; protein phosphatase 1, regulatory (inhibitor) subunit 3A; Protein phosphatase type-1 glycogen targeting subunit; RG1; serine /threonine specific protein phosphatase; type-1 protein phosphatase skeletal muscle glycogen targeting subunit
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Gene Symbols: PPP1R3A
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Molecular weight:
125,767 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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