|
SLC6A12
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
|
Cellular Component:
basolateral plasma membrane; plasma membrane
|
|
Molecular Function:
gamma-aminobutyric acid:sodium:chloride symporter activity
|
|
Biological Process:
gamma-aminobutyric acid transport; glycine betaine transport; monocarboxylic acid transport; neurotransmitter transport
|
|
Reference #:
P27799
(UniProtKB)
|
|
Alt. Names/Synonyms: Na /Cl- betaine/GABA transporter; S6A12; S6AC; SLC6A12; Sodium- and chloride-dependent betaine transporter; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
|
|
Gene Symbols: SLC6A12
|
|
Molecular weight:
69,292 Da
|
|
Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
|
