CXCR4 Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Belongs to the G-protein coupled receptor 1 family. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1 E3|1 56.43 cM
Cellular Component:  cell junction; cell leading edge; cell surface; cell-cell junction; cytoplasm; cytoplasmic vesicle; early endosome; endosome; external side of plasma membrane; growth cone; integral component of membrane; late endosome; lysosome; membrane; nucleus; plasma membrane; protein-containing complex
Molecular Function:  actin binding; C-C chemokine binding; C-C chemokine receptor activity; C-X-C chemokine receptor activity; C-X-C motif chemokine 12 receptor activity; chemokine binding; chemokine receptor activity; cytokine binding; drug binding; G protein-coupled receptor activity; myosin light chain binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  ameboidal-type cell migration; animal organ morphogenesis; aorta development; brain development; branching involved in blood vessel morphogenesis; calcium-mediated signaling; cardiac muscle contraction; cell chemotaxis; cell migration; cellular response to cytokine stimulus; chemotaxis; CXCL12-activated CXCR4 signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; endothelial cell differentiation; endothelial tube morphogenesis; epithelial cell development; G protein-coupled receptor signaling pathway; generation of neurons; germ cell development; germ cell migration; hematopoietic stem cell migration; immune response; motor neuron axon guidance; myelin maintenance; nervous system development; neural precursor cell proliferation; neurogenesis; neuron migration; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of chemotaxis; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of dendrite extension; positive regulation of mesenchymal stem cell migration; positive regulation of neurogenesis; positive regulation of oligodendrocyte differentiation; positive regulation of protein phosphorylation; positive regulation of vascular wound healing; regulation of calcium ion transport; regulation of cell adhesion; regulation of cell migration; regulation of chemotaxis; regulation of programmed cell death; regulation of viral process; signal transduction; T cell proliferation; telencephalon cell migration; ventricular septum development
Reference #:  P70658 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 4; CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; Cmkar4; CXC-R4; CXCR-4; Cxcr4; Fusin; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; OTTMUSP00000022912; PB-CKR; PBSF/SDF-1; Pre-B-cell-derived chemokine receptor; SDF-1 receptor; Sdf1r; Stromal cell-derived factor 1 receptor
Gene Symbols: Cxcr4
Molecular weight: 40,426 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene