CXCR4 Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Belongs to the G-protein coupled receptor 1 family. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 2q22.1
Cellular Component:  cell junction; cell leading edge; cell surface; cytoplasm; cytoplasmic vesicle; early endosome; integral component of membrane; late endosome; lysosome; nucleus; plasma membrane; protein-containing complex
Molecular Function:  actin binding; C-C chemokine binding; C-X-C chemokine receptor activity; C-X-C motif chemokine 12 receptor activity; coreceptor activity; drug binding; G protein-coupled receptor activity; myosin light chain binding; protein binding; ubiquitin binding; ubiquitin protein ligase binding; virus receptor activity
Biological Process:  activation of MAPK activity; apoptotic process; axon guidance; calcium-mediated signaling; cardiac muscle contraction; cellular response to cytokine stimulus; cellular response to drug; CXCL12-activated CXCR4 signaling pathway; dendritic cell chemotaxis; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; endothelial cell differentiation; endothelial tube morphogenesis; entry into host cell; epithelial cell development; fusion of virus membrane with host plasma membrane; G protein-coupled receptor signaling pathway; inflammatory response; myelin maintenance; neuron migration; neuron recognition; positive regulation of chemotaxis; positive regulation of cold-induced thermogenesis; positive regulation of dendrite extension; positive regulation of mesenchymal stem cell migration; positive regulation of oligodendrocyte differentiation; positive regulation of vascular wound healing; regulation of calcium ion transport; regulation of cell adhesion; regulation of chemotaxis; regulation of programmed cell death; regulation of viral process; response to activity; response to hypoxia; response to morphine; response to ultrasound; response to virus; telencephalon cell migration
Disease: Whim Syndrome
Reference #:  P61073 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 4; C-X-C motif chemokine receptor 4; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; CXC-R4; CXCR-4; CXCR4; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIM; WHIMS
Gene Symbols: CXCR4
Molecular weight: 39,746 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein