PSD-95 Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Belongs to the MAGUK family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  AMPA glutamate receptor complex; anchored component of postsynaptic density membrane; cell junction; cell periphery; cell-cell junction; cerebellar mossy fiber; cortical cytoskeleton; cytoplasm; cytosol; dendrite; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; excitatory synapse; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; juxtaparanode region of axon; membrane; neuromuscular junction; neuron projection; neuron projection terminus; neuron spine; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synapse; synaptic membrane; synaptic vesicle
Molecular Function:  acetylcholine receptor binding; beta-1 adrenergic receptor binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding; frizzled binding; glutamate receptor binding; immunoglobulin binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; neuroligin family protein binding; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; scaffold protein binding; signaling receptor binding; structural constituent of postsynaptic density
Biological Process:  AMPA glutamate receptor clustering; cell-cell adhesion; cellular response to potassium ion; chemical synaptic transmission; dendritic spine morphogenesis; dendritic spine organization; establishment of protein localization; locomotory exploration behavior; maintenance of postsynaptic density structure; negative regulation of receptor internalization; neuromuscular process controlling balance; neuronal ion channel clustering; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of cytosolic calcium ion concentration; positive regulation of excitatory postsynaptic potential; positive regulation of neuron projection arborization; positive regulation of protein tyrosine kinase activity; positive regulation of synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; protein localization to synapse; protein-containing complex assembly; receptor clustering; receptor localization to synapse; regulation of grooming behavior; regulation of long-term neuronal synaptic plasticity; regulation of NMDA receptor activity; social behavior; synaptic vesicle maturation; vocalization behavior
Reference #:  P31016 (UniProtKB)
Alt. Names/Synonyms: discs large homolog 4; discs, large homolog 4 (Drosophila); Disks large homolog 4; Dlg4; Dlgh4; Postsynaptic density protein 95; PSD-95; Psd95; SAP-90; SAP90; Synapse-associated protein 90; synapse-associated protein SAP90
Gene Symbols: Dlg4
Molecular weight: 80,465 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene