DLG3 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Belongs to the MAGUK family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq22
Cellular Component:  AMPA glutamate receptor complex; basolateral plasma membrane; bicellular tight junction; cell junction; cell-cell junction; cytoplasm; dendritic shaft; glutamatergic synapse; growth cone; neuromuscular junction; neuron projection; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic density, intracellular component; synapse
Molecular Function:  ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein domain specific binding; protein phosphatase binding; structural constituent of postsynaptic density; ubiquitin protein ligase binding
Biological Process:  cell-cell adhesion; chemical synaptic transmission; establishment of planar polarity; establishment or maintenance of epithelial cell apical/basal polarity; maintenance of postsynaptic density structure; negative regulation of phosphatase activity; positive regulation of protein tyrosine kinase activity; receptor clustering; receptor localization to synapse; regulation of postsynaptic membrane neurotransmitter receptor levels
Reference #:  Q62936 (UniProtKB)
Alt. Names/Synonyms: discs large homolog 3; discs, large homolog 3 (Drosophila); Disks large homolog 3; Dlg3; Dlgh3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; Synapse-associated protein 102
Gene Symbols: Dlg3
Molecular weight: 93,539 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene