PSD-95
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Belongs to the MAGUK family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of mouse Ortholog: 11|11 B3 |
Cellular Component:
AMPA glutamate receptor complex; basolateral plasma membrane; cell junction; cell periphery; cell projection; cell-cell junction; cerebellar mossy fiber; cortical cytoskeleton; cytoplasm; dendrite; dendrite cytoplasm; dendritic branch; dendritic spine; endoplasmic reticulum; excitatory synapse; glutamatergic synapse; juxtaparanode region of axon; membrane; neuromuscular junction; neuron projection; neuron projection terminus; neuron spine; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; proximal dendrite; synapse; synaptic membrane; synaptic vesicle
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Molecular Function:
acetylcholine receptor binding; beta-1 adrenergic receptor binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding; frizzled binding; glutamate receptor binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; neurexin family protein binding; neuroligin family protein binding; P2Y1 nucleotide receptor binding; PDZ domain binding; protein binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; scaffold protein binding; signaling receptor binding; structural constituent of postsynaptic density; structural molecule activity
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Biological Process:
AMPA glutamate receptor clustering; cell-cell adhesion; cellular response to potassium ion; chemical synaptic transmission; dendritic spine morphogenesis; dendritic spine organization; embryo development; establishment of protein localization; establishment or maintenance of epithelial cell apical/basal polarity; locomotory behavior; locomotory exploration behavior; negative regulation of receptor internalization; neuromuscular process controlling balance; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of AMPA glutamate receptor clustering; positive regulation of cytosolic calcium ion concentration; positive regulation of dendrite morphogenesis; positive regulation of excitatory postsynaptic potential; positive regulation of neuron projection arborization; positive regulation of protein tyrosine kinase activity; positive regulation of synapse assembly; positive regulation of synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; protein localization to synapse; protein-containing complex assembly; receptor localization to synapse; regulation of grooming behavior; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; response to cocaine; social behavior; synaptic vesicle maturation; vocalization behavior
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Reference #:
Q62108
(UniProtKB)
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Alt. Names/Synonyms: discs large homolog 4; discs large MAGUK scaffold protein 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); Disks large homolog 4; Dlg4; Dlgh; Dlgh4; OTTMUSP00000006269; Postsynaptic density protein 95; PSD; PSD-; PSD-95; PSD-95 alpha 2b; PSD-95 beta; Psd95; RP23-172M21.9; SAP-90; SAP90; SAP90A; Synapse-associated protein 90
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Gene Symbols: Dlg4
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Molecular weight:
80,472 Da
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Basal Isoelectric point:
5.56
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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