TUBB1
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 20q13.32 |
Cellular Component:
cytoplasm; intercellular bridge; microtubule; microtubule cytoskeleton; mitotic spindle
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Molecular Function:
GTP binding; GTPase activity; metal ion binding; structural constituent of cytoskeleton
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Biological Process:
microtubule cytoskeleton organization; microtubule polymerization; mitotic cell cycle; platelet aggregation; platelet formation; spindle assembly; thyroid gland development; thyroid hormone transport
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Disease: Macrothrombocytopenia, Autosomal Dominant, Tubb1-related
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Reference #:
Q9H4B7
(UniProtKB)
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Alt. Names/Synonyms: beta tubulin 1, class VI; dJ543J19.4; TBB1; TUBB1; tubulin beta 1 class VI; Tubulin beta-1 chain; tubulin, beta 1
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Gene Symbols: TUBB1
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Molecular weight:
50,327 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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