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IkB-epsilon
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Inhibitor |
| Chromosomal Location of Human Ortholog: 17|17 B3 |
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Cellular Component:
cytoplasm; cytosol; fibrillar center; Golgi apparatus; nucleus; perinuclear region of cytoplasm
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Molecular Function:
protein binding
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Biological Process:
D-serine transport; negative regulation of transcription, DNA-templated
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Reference #:
O54910
(UniProtKB)
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Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; Ikbe; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
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Gene Symbols: Nfkbie
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Molecular weight:
39,200 Da
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Basal Isoelectric point:
4.63
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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