IkB-epsilon Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Belongs to the NF-kappa-B inhibitor family. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Inhibitor
Chromosomal Location of mouse Ortholog: 17|17 B3
Cellular Component:  cytoplasm; cytosol; fibrillar center; nucleoplasm; perinuclear region of cytoplasm
Molecular Function:  protein binding
Biological Process:  D-serine transport; negative regulation of DNA-templated transcription
Reference #:  O54910 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-epsilon; IkappaBepsilon; IkB-E; IkB-epsilon; Ikbe; NF-kappa-B inhibitor epsilon; NF-kappa-BIE; Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Gene Symbols: Nfkbie
Molecular weight: 39,200 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein