HDAC6 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. Belongs to the histone deacetylase family. HD type 2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of mouse Ortholog: X A1.1|X 3.58 cM
Cellular Component:  aggresome; axon; caveola; cell body; cell leading edge; cell projection; centrosome; cytoplasm; cytosol; dendrite; histone deacetylase complex; inclusion body; microtubule; microtubule associated complex; neuron projection; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; protein-containing complex
Molecular Function:  actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; deacetylase activity; dynein complex binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; hydrolase activity; metal ion binding; microtubule binding; misfolded protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); polyubiquitin modification-dependent protein binding; protein binding; protein deacetylase activity; RNA polymerase II proximal promoter sequence-specific DNA binding; tau protein binding; tubulin deacetylase activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  aggresome assembly; cellular response to hydrogen peroxide; cellular response to misfolded protein; cellular response to topologically incorrect protein; chromatin organization; collateral sprouting; dendritic spine morphogenesis; histone deacetylation; Hsp90 deacetylation; intracellular protein transport; lysosome localization; mitochondrion localization; myotube differentiation; negative regulation of microtubule depolymerization; negative regulation of protein complex disassembly; negative regulation of proteolysis; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; peptidyl-lysine deacetylation; polyubiquitinated misfolded protein transport; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of mitophagy in response to mitochondrial depolarization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein oligomerization; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein deacetylation; protein polyubiquitination; protein quality control for misfolded or incompletely synthesized proteins; protein-containing complex disassembly; regulation of establishment of protein localization; regulation of fat cell differentiation; regulation of gene expression, epigenetic; regulation of macroautophagy; regulation of protein stability; regulation of signaling receptor activity; response to growth factor; response to misfolded protein; response to organic substance; response to toxic substance; skeletal muscle tissue development; tubulin deacetylation; ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Reference #:  Q9Z2V5 (UniProtKB)
Alt. Names/Synonyms: Hd6; Hdac5; Hdac6; Hdac6 protein; histone deacetylase 5; Histone deacetylase 6; histone deacetylase mHDA2; mHDA; mHDA2; OTTMUSP00000018679; scurfy candidate 6; Sfc; Sfc6; Tubulin-lysine deacetylase HDAC6
Gene Symbols: Hdac6
Molecular weight: 125,787 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA