CDKL5 Mediates phosphorylation of MECP2. May regulate ciliogenesis. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDKL family; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: X F4|X 73.95 cM
Cellular Component:  cell projection; centrosome; ciliary basal body; ciliary tip; cytoplasm; cytoskeleton; cytosol; dendrite cytoplasm; dendritic growth cone; glutamatergic synapse; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density, intracellular component; synapse
Molecular Function:  ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding; transferase activity
Biological Process:  neuron migration; phosphorylation; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine development; positive regulation of GTPase activity; protein autophosphorylation; protein phosphorylation; regulation of cilium assembly; regulation of dendrite development; regulation of postsynapse organization
Reference #:  Q3UTQ8 (UniProtKB)
Alt. Names/Synonyms: BC038161; Cdkl5; Cyclin-dependent kinase-like 5; serine/threonine kinase 9; Stk9
Gene Symbols: Cdkl5
Molecular weight: 105,489 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
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CDKL5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene