|
RGS10 iso1
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: GAP; GAP, RGS |
| Chromosomal Location of human Ortholog: 10q26.11 |
|
Cellular Component:
cytosol; nuclear body; nucleoplasm; nucleus; plasma membrane; synapse
|
|
Molecular Function:
G-protein alpha-subunit binding; GTPase activator activity; GTPase activity; protein binding
|
|
Biological Process:
G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
|
|
Reference #:
O43665-1
(UniProtKB)
|
|
Alt. Names/Synonyms: regulator of G protein signaling 10; Regulator of G-protein signaling 10; regulator of G-protein signalling 10; RGS10; RGS10 iso1
|
|
Gene Symbols: RGS10
|
|
Molecular weight:
20,236 Da
|
|
Basal Isoelectric point:
5.35
Predict pI for various phosphorylation states
|
|
CST Pathways:
GPCR Signaling to MAPKs
|
