PPBP LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 4q13.3
Cellular Component:  extracellular region; platelet alpha granule lumen; tertiary granule lumen
Molecular Function:  glucose transmembrane transporter activity; growth factor activity; protein binding
Biological Process:  defense response to bacterium; G protein-coupled receptor signaling pathway; glucose transmembrane transport; neutrophil degranulation; platelet degranulation; positive regulation of cell division; regulation of signaling receptor activity
Reference #:  P02775 (UniProtKB)
Alt. Names/Synonyms: B-TG1; Beta-TG; Beta-thromboglobulin; C-X-C motif chemokine 7; chemokine (C-X-C motif) ligand 7; Connective tissue-activating peptide III; Connective tissue-activating peptide III(1-81); CTAP-III; CTAP-III(1-81); CTAP3; CTAPIII; CXC chemokine ligand 7; CXCL7; LA-PF4; LDGF; Leukocyte-derived growth factor; Low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; NAP-2; NAP-2(1-63); NAP-2(1-66); NAP-2(73); NAP-2(74); Neutrophil-activating peptide 2; Neutrophil-activating peptide 2(1-63); Neutrophil-activating peptide 2(1-66); Neutrophil-activating peptide 2(73); Neutrophil-activating peptide 2(74); neutrophil-activating peptide-2; PBP; Platelet basic protein; PPBP; pro-platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); SCYB7; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible cytokine B7; TC-1; TC-2; TC1; TC2; TGB; TGB1; THBGB; THBGB1; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1
Gene Symbols: PPBP
Molecular weight: 13,894 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below

PPBP

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene