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PPBP
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
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| Protein type: Chemokine; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 4q13.3 |
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Cellular Component:
extracellular region; extracellular space; platelet alpha granule lumen; tertiary granule lumen
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Molecular Function:
chemokine activity; CXCR chemokine receptor binding; glucose transmembrane transporter activity; growth factor activity; protein binding
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Biological Process:
antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; defense response to bacterium; glucose transmembrane transport; inflammatory response; neutrophil chemotaxis; positive regulation of cell division
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Reference #:
P02775
(UniProtKB)
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Alt. Names/Synonyms: B-TG1; Beta-TG; Beta-thromboglobulin; C-X-C motif chemokine 7; chemokine (C-X-C motif) ligand 7; Connective tissue-activating peptide III; Connective tissue-activating peptide III(1-81); CTAP-III; CTAP-III(1-81); CTAP3; CTAPIII; CXC chemokine ligand 7; CXCL7; LA-PF4; LDGF; Leukocyte-derived growth factor; Low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; NAP-2; NAP-2(1-63); NAP-2(1-66); NAP-2(73); NAP-2(74); Neutrophil-activating peptide 2; Neutrophil-activating peptide 2(1-63); Neutrophil-activating peptide 2(1-66); Neutrophil-activating peptide 2(73); Neutrophil-activating peptide 2(74); neutrophil-activating peptide-2; PBP; Platelet basic protein; PPBP; pro-platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); SCYB7; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible cytokine B7; TC-1; TC-2; TC1; TC2; TGB; TGB1; THBGB; THBGB1; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1
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Gene Symbols: PPBP
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Molecular weight:
13,894 Da
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Basal Isoelectric point:
9.04
Predict pI for various phosphorylation states
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