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PARVB
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Belongs to the parvin family. Expressed predominantly in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 22q13.31 |
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Cellular Component:
actin cytoskeleton; cytoplasm; cytosol; focal adhesion; lamellipodium; plasma membrane; Z disc
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Molecular Function:
actin binding; protein binding
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Biological Process:
actin cytoskeleton organization; cell projection assembly; establishment or maintenance of cell polarity; establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; substrate adhesion-dependent cell spreading
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Reference #:
Q9HBI1
(UniProtKB)
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Alt. Names/Synonyms: Affixin; Beta-parvin; CGI-56; PARVB; parvin beta; parvin, beta
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Gene Symbols: PARVB
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Molecular weight:
41,714 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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