PARVB Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Belongs to the parvin family. Expressed predominantly in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component:  cytosol; focal adhesion; lamellipodium; plasma membrane; Z disc
Molecular Function:  protein binding
Biological Process:  actin cytoskeleton reorganization; cell projection assembly; establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly
Reference #:  Q9HBI1 (UniProtKB)
Alt. Names/Synonyms: Affixin; Beta-parvin; CGI-56; PARVB; parvin beta; parvin, beta
Gene Symbols: PARVB
Molecular weight: 41,714 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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PARVB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB