ING4 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11. Belongs to the ING family. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  cytosol; histone acetyltransferase complex; intermediate filament cytoskeleton; nucleoplasm; nucleus
Molecular Function:  metal ion binding; methylated histone binding; protein binding; transcription coactivator activity
Biological Process:  apoptotic process; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA replication; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; negative regulation of cell proliferation; negative regulation of growth; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process; positive regulation of nucleic acid-templated transcription; protein acetylation
Reference #:  Q9UNL4 (UniProtKB)
Alt. Names/Synonyms: brain my036 protein; candidate tumor suppressor p33 ING1 homolog; ING4; inhibitor of growth family member 4; inhibitor of growth family, member 4; Inhibitor of growth protein 4; MGC12557; my036; p29ING4
Gene Symbols: ING4
Molecular weight: 28,530 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein