glutaminase Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Belongs to the glutaminase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component:  cytosol; mitochondrial matrix; mitochondrion
Molecular Function:  glutaminase activity; protein binding
Biological Process:  cellular amino acid biosynthetic process; chemical synaptic transmission; glutamate biosynthetic process; glutamate secretion; glutamine catabolic process; protein homotetramerization; regulation of respiratory gaseous exchange by neurological system process; suckling behavior
Disease: Diamond-blackfan Anemia 19; Epileptic Encephalopathy, Early Infantile, 71; Infantile Cataract, Skin Abnormalities, Glutamate Excess, And Impaired Intellectual Development
Reference #:  O94925 (UniProtKB)
Alt. Names/Synonyms: AAD20; DKFZp686O15119; FLJ10358; GLS; GLS1; GLSK; glutaminase; glutaminase C; Glutaminase kidney isoform, mitochondrial; glutaminase, phosphate-activated; K-glutaminase; KIAA0838; L-glutamine amidohydrolase
Gene Symbols: GLS
Molecular weight: 73,461 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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glutaminase

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene