G6B Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  endoplasmic reticulum; Golgi apparatus; integral component of membrane; plasma membrane
Molecular Function:  heparin binding; protein binding
Biological Process:  blood coagulation; erythrocyte differentiation; integrin-mediated signaling pathway; megakaryocyte development; megakaryocyte differentiation; negative regulation of signal transduction; platelet activation; platelet formation
Disease: Thrombocytopenia, Anemia, And Myelofibrosis
Reference #:  O95866 (UniProtKB)
Alt. Names/Synonyms: C6orf25; G6B; G6B-B; immunoglobulin receptor; Megakaryocyte and platelet inhibitory receptor G6b; MGC142279; MGC142281; MPIG6B; NG31; Protein G6b; THAMY
Gene Symbols: MPIG6B
Molecular weight: 26,163 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein