AKAP8 Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1. Belongs to the AKAP95 family. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding
Chromosomal Location of mouse Ortholog: 17|17 B1
Cellular Component:  condensed chromosome; cytoplasm; female pronucleus; Golgi apparatus; mitochondrion; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; double-stranded DNA binding; histone deacetylase binding; metal ion binding; NF-kappaB binding; protein binding; protein kinase A regulatory subunit binding; zinc ion binding
Biological Process:  cell cycle G2/M phase transition; cellular response to lipopolysaccharide; cellular response to prostaglandin E stimulus; immune system process; innate immune response; mitotic chromosome condensation; negative regulation of tumor necrosis factor production; positive regulation of histone deacetylation; protein transport; regulation of histone phosphorylation
Reference #:  Q9DBR0 (UniProtKB)
Alt. Names/Synonyms: 1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; A kinase anchor protein 95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AA673585; AKA; AKAP 95; AKAP-8; Akap8; Akap95; AU015639
Gene Symbols: Akap8
Molecular weight: 76,294 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene