AKAP1 Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding
Chromosomal Location of Human Ortholog: 11|11 C
Cellular Component:  endoplasmic reticulum; integral component of membrane; lipid droplet; membrane; mitochondrial crista; mitochondrial outer membrane; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function:  beta-tubulin binding; microtubule binding; molecular adaptor activity; nucleic acid binding; protein binding; protein kinase A regulatory subunit binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding; RNA binding
Biological Process:  negative regulation of cardiac muscle hypertrophy; negative regulation of protein dephosphorylation; negative regulation of protein import into nucleus; regulation of protein kinase A signaling
Reference #:  O08715 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 1; A kinase anchor protein 1, mitochondrial; A-kinase anchor protein 1, mitochondrial; AKA; Akap; Akap1; AKAP121; AKAP84; C76494; C81186; D-AKAP-1; DAK; DAKAP1; Dual specificity A-kinase-anchoring protein 1; OTTMUSP00000001248; OTTMUSP00000001249; PRKA1; Protein kinase A-anchoring protein 1; S-AK; S-AKAP; S-AKAP84; Spermatid A-kinase anchor protein
Gene Symbols: Akap1
Molecular weight: 92,195 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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AKAP1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene