ADCY1 a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 11 A1|11 4.72 cM
Cellular Component:  cytoplasm; integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; lyase activity; metal ion binding; nucleotide binding; phosphorus-oxygen lyase activity
Biological Process:  adenylate cyclase activation; adenylate cyclase-activating G-protein coupled receptor signaling pathway; axonogenesis; cAMP biosynthetic process; cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; long-term memory; regulation of circadian rhythm; rhythmic process
Reference #:  O88444 (UniProtKB)
Alt. Names/Synonyms: AC1; Adcy1; adenylate cyclase 1; Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate-lyase 1; barrelless; brl; Ca(2+)/calmodulin-activated adenylyl cyclase; D11Bwg1392e; I-AC; KIAA4070; mKIAA4070; OTTMUSP00000005342
Gene Symbols: Adcy1
Molecular weight: 123,373 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene