|
ADCY1
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla. Note: This description may include information from UniProtKB.
|
| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of mouse Ortholog: 11 A1|11 4.72 cM |
|
Cellular Component:
cytoplasm; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; plasma membrane; postsynaptic density; postsynaptic density membrane; Schaffer collateral - CA1 synapse
|
|
Molecular Function:
adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; lyase activity; metal ion binding; nucleotide binding; phosphorus-oxygen lyase activity
|
|
Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; axonogenesis; cAMP biosynthetic process; cyclic nucleotide biosynthetic process; intracellular signal transduction; long-term memory; modulation of chemical synaptic transmission; neuroinflammatory response; positive regulation of CREB transcription factor activity; positive regulation of long-term synaptic potentiation; presynaptic modulation of chemical synaptic transmission; regulation of circadian rhythm; rhythmic process
|
|
Reference #:
O88444
(UniProtKB)
|
|
Alt. Names/Synonyms: AC1; Adcy1; Adenylate Cyclase; adenylate cyclase 1; Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate-lyase 1; barrelless; brl; Ca(2+)/calmodulin-activated adenylyl cyclase; D11Bwg1392e; I-AC; KIAA4070; mKIAA4070; OTTMUSP00000005342
|
|
Gene Symbols: Adcy1
|
|
Molecular weight:
123,373 Da
|
|
Basal Isoelectric point:
8.81
Predict pI for various phosphorylation states
|
|
CST Pathways:
GPCR Signaling to MAPKs
|
NF-kB Signaling
|
Parkinson's Disease
|
