ADCY1 a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 11 A1|11 4.72 cM
Cellular Component:  cytoplasm; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; membrane; nucleus; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse
Molecular Function:  adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; lyase activity; metal ion binding; nucleotide binding; phosphorus-oxygen lyase activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; axonogenesis; cAMP biosynthetic process; cyclic nucleotide biosynthetic process; intracellular signal transduction; long-term memory; modulation of chemical synaptic transmission; neuroinflammatory response; positive regulation of CREB transcription factor activity; positive regulation of long-term synaptic potentiation; regulation of circadian rhythm; regulation of synaptic vesicle exocytosis; rhythmic process
Reference #:  O88444 (UniProtKB)
Alt. Names/Synonyms: AC1; Adcy1; adenylate cyclase 1; Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate-lyase 1; barrelless; brl; Ca(2+)/calmodulin-activated adenylyl cyclase; D11Bwg1392e; I-AC; KIAA4070; mKIAA4070; OTTMUSP00000005342
Gene Symbols: Adcy1
Molecular weight: 123,373 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene