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ABCB9
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family |
| Chromosomal Location of mouse Ortholog: 5|5 F |
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Cellular Component:
endoplasmic reticulum membrane; intracellular membrane-bounded organelle; lysosomal membrane; lysosome; membrane
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Molecular Function:
ABC-type oligopeptide transporter activity; ABC-type peptide transporter activity; ABC-type transporter activity; ATP binding; ATP hydrolysis activity; ATPase-coupled transmembrane transporter activity; nucleotide binding; protein homodimerization activity; transmembrane transporter activity
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Biological Process:
peptide metabolic process; peptide transport; protein transport; transmembrane transport
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Reference #:
Q9JJ59
(UniProtKB)
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Alt. Names/Synonyms: ABC transporter 9 protein; ABC-type oligopeptide transporter ABCB9; Abcb9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; ATP-binding cassette, sub-family B, member 9; Kiaa1520; mABCB9; mKIAA1520; TAP-like protein; TAPL
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Gene Symbols: Abcb9
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Molecular weight:
83,963 Da
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Basal Isoelectric point:
7.3
Predict pI for various phosphorylation states
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