ADCY3 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of rat Ortholog: 6q14
Cellular Component:  cilium; cytoplasm; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; nucleus; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding
Biological Process:  acrosome reaction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to forskolin; flagellated sperm motility; olfactory learning; sensory perception of smell; single fertilization
Reference #:  P21932 (UniProtKB)
Alt. Names/Synonyms: AC-III; AC3; Adcy3; adenylate cyclase 3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase
Gene Symbols: Adcy3
Molecular weight: 128,936 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene