ADCY3 a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Involved in odorant detection (possibly) via modulation of intracellular cAMP concentration. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 6q14
Cellular Component:  cilium; cytoplasm; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; nucleus; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding
Biological Process:  acrosome reaction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to forskolin; flagellated sperm motility; olfactory learning; sensory perception of smell; single fertilization
Reference #:  P21932 (UniProtKB)
Alt. Names/Synonyms: AC-III; AC3; Adcy3; adenylate cyclase 3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase
Gene Symbols: Adcy3
Molecular weight: 128,936 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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ADCY3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene