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ADCY3
a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Involved in odorant detection (possibly) via modulation of intracellular cAMP concentration. Note: This description may include information from UniProtKB.
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| Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family |
| Chromosomal Location of Human Ortholog: 6q14 |
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Cellular Component:
cilium; cytoplasm; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; nucleus; plasma membrane
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Molecular Function:
adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding
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Biological Process:
acrosome reaction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to forskolin; flagellated sperm motility; olfactory learning; sensory perception of smell; single fertilization
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Reference #:
P21932
(UniProtKB)
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Alt. Names/Synonyms: AC-III; AC3; Adcy3; adenylate cyclase 3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase
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Gene Symbols: Adcy3
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Molecular weight:
128,936 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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NF-kB Signaling
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Parkinson's Disease
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