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FRMD4B
Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 3p14.1 |
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Cellular Component:
adherens junction; bicellular tight junction; cytoplasm; cytoskeleton; ruffle
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Biological Process:
establishment of epithelial cell polarity
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Reference #:
Q9Y2L6
(UniProtKB)
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Alt. Names/Synonyms: 6030440G05Rik; FERM domain containing 4B; FERM domain-containing protein 4B; FRM4B; FRMD4B; GRP1-binding protein GRSP1; GRSP1; KIAA1013
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Gene Symbols: FRMD4B
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Molecular weight:
118,047 Da
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Basal Isoelectric point:
8.79
Predict pI for various phosphorylation states
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