SAHH Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Belongs to the adenosylhomocysteinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component:  cytosol; melanosome; neuron projection; nucleus
Molecular Function:  adenosylhomocysteinase activity; adenyl nucleotide binding; identical protein binding; NAD binding; protein binding
Biological Process:  chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; methylation; one-carbon metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; sulfur amino acid metabolic process
Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
Reference #:  P23526 (UniProtKB)
Alt. Names/Synonyms: Adenosylhomocysteinase; AdoHcyase; AHCY; epididymis secretory sperm binding protein; S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; SAHH
Gene Symbols: AHCY
Molecular weight: 47,716 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Select Structure to View Below

SAHH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein