NIF3L1 May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. Belongs to the GTP cyclohydrolase I type 2/NIF3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 2q33.1
Cellular Component:  cytoplasm; mitochondrion; nucleus
Molecular Function:  identical protein binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of DNA-templated transcription
Reference #:  Q9GZT8 (UniProtKB)
Alt. Names/Synonyms: ALS2CR1; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein; CALS-7; GTP cyclohydrolase I; MDS015; NGG1 interacting factor 3 like 1; NIF3 (Ngg1 interacting factor 3, S.pombe homolog)-like 1; NIF3 NGG1 interacting factor 3-like 1; NIF3 NGG1 interacting factor 3-like 1 (S. pombe); NIF3-like protein 1; NIF3L; NIF3L1; putative GTP cyclohydrolase 1 type 2 NIF3L1
Gene Symbols: NIF3L1
Molecular weight: 41,968 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein