neurobeachin Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Belongs to the WD repeat neurobeachin family. Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component:  cytosol; endomembrane system; plasma membrane; trans-Golgi network
Molecular Function:  protein kinase binding
Biological Process:  protein localization
Disease: Neurodevelopmental Disorder With Or Without Early-onset Generalized Epilepsy
Reference #:  Q8NFP9 (UniProtKB)
Alt. Names/Synonyms: BCL8B; KIAA1544; lysosomal trafficking regulator 2; Lysosomal-trafficking regulator 2; LYST2; NBEA; Neurobeachin; Protein BCL8B
Gene Symbols: NBEA
Molecular weight: 327,822 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
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neurobeachin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein