MTA2 May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  histone deacetylase complex; nucleoplasm; NuRD complex; transcription factor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase activity; protein binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding; zinc ion binding
Biological Process:  chromatin assembly or disassembly; DNA methylation; positive regulation of transcription by RNA polymerase II; regulation of fibroblast migration; regulation of signal transduction by p53 class mediator
Reference #:  O94776 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F2281; metastasis -associated gene 1-like 1; metastasis associated 1 family, member 2; metastasis associated gene family, member 2; Metastasis-associated 1-like 1; metastasis-associated protein 2; Metastasis-associated protein MTA2; MTA1-L1 protein; MTA1L1; MTA2; p53 target protein in deacetylase complex; PID
Gene Symbols: MTA2
Molecular weight: 75,023 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA