GOT1 Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC; EC; Transferase
Chromosomal Location of human Ortholog: 10q24.2
Cellular Component:  axon terminus; cytoplasm; cytosol; lysosome; nucleoplasm
Molecular Function:  carboxylic acid binding; L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; phosphatidylserine decarboxylase activity; pyridoxal phosphate binding
Biological Process:  2-oxoglutarate metabolic process; aspartate catabolic process; aspartate metabolic process; cellular amino acid biosynthetic process; cellular response to insulin stimulus; cellular response to mechanical stimulus; fatty acid homeostasis; gluconeogenesis; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; glycerol biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; Notch signaling pathway; oxaloacetate metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; response to cadmium ion; response to carbohydrate; response to glucocorticoid; response to immobilization stress; response to transition metal nanoparticle; transdifferentiation
Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1
Reference #:  P17174 (UniProtKB)
Alt. Names/Synonyms: AATC; aspartate aminotransferase 1; Aspartate aminotransferase, cytoplasmic; aspartate transaminase 1; AST1; ASTQTL1; cAspAT; cCAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; GIG18; Glutamate oxaloacetate transaminase 1; glutamic-oxaloacetic transaminase 1; glutamic-oxaloacetic transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); GOT1; growth-inhibiting protein 18; testis secretory sperm-binding protein Li 196a; Transaminase A
Gene Symbols: GOT1
Molecular weight: 46,248 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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