GOT1 Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC; EC; Transferase
Chromosomal Location of mouse Ortholog: 19 C3|19 36.67 cM
Cellular Component:  axon terminus; cytoplasm; cytosol
Molecular Function:  carboxylic acid binding; catalytic activity; L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine transaminase activity; phosphatidylserine decarboxylase activity; pyridoxal phosphate binding; transaminase activity; transferase activity
Biological Process:  amino acid biosynthetic process; amino acid metabolic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; biosynthetic process; cellular response to mechanical stimulus; dicarboxylic acid metabolic process; fatty acid homeostasis; gluconeogenesis; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glycerol biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; Notch signaling pathway; oxaloacetate metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; response to transition metal nanoparticle; transdifferentiation
Reference #:  P05201 (UniProtKB)
Alt. Names/Synonyms: AATC; AI789014; Aspartate aminotransferase, cytoplasmic; cAspAT; cCAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble; Got-; Got-1; Got1; OTTMUSP00000027809; Transaminase A
Gene Symbols: Got1
Molecular weight: 46,248 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein