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GOT1
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.3; Transferase |
| Chromosomal Location of mouse Ortholog: 19 C3|19 36.67 cM |
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Cellular Component:
axon terminus; cytoplasm; cytosol
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Molecular Function:
carboxylic acid binding; catalytic activity; L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine transaminase activity; phosphatidylserine decarboxylase activity; pyridoxal phosphate binding; transaminase activity; transferase activity
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Biological Process:
amino acid biosynthetic process; amino acid metabolic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; biosynthetic process; cellular response to mechanical stimulus; dicarboxylic acid metabolic process; fatty acid homeostasis; gluconeogenesis; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glycerol biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of cytosolic calcium ion concentration; negative regulation of mitochondrial depolarization; Notch signaling pathway; oxaloacetate metabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; response to transition metal nanoparticle; transdifferentiation
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Reference #:
P05201
(UniProtKB)
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Alt. Names/Synonyms: AATC; AI789014; Aspartate aminotransferase, cytoplasmic; cAspAT; cCAT; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble; Got-; Got-1; Got1; OTTMUSP00000027809; Transaminase A
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Gene Symbols: Got1
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Molecular weight:
46,248 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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