FOXN3 Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q31.3-q32.11
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein C-terminus binding; sequence-specific DNA binding
Biological Process:  craniofacial suture morphogenesis; mitotic G2 DNA damage checkpoint; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II
Reference #:  O00409 (UniProtKB)
Alt. Names/Synonyms: C14orf116; Checkpoint suppressor 1; CHES1; forkhead box N3; Forkhead box protein N3; FOXN3; PRO1635
Gene Symbols: FOXN3
Molecular weight: 53,835 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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