LATS2 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of human Ortholog: 13q12.11
Cellular Component:  cytosol; microtubule organizing center; nucleus; spindle pole
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cell division; G1/S transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; protein phosphorylation
Reference #:  Q9NRM7 (UniProtKB)
Alt. Names/Synonyms: FLJ13161; Kinase phosphorylated during mitosis protein; KPM; Large tumor suppressor homolog 2; large tumor suppressor kinase 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Warts-like kinase
Gene Symbols: LATS2
Molecular weight: 120,136 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LATS2

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