PLXNC1 Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family. Detected in heart, brain, lung, spleen and placenta. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 12q22
Cellular Component:  cerebellar climbing fiber to Purkinje cell synapse; plasma membrane; semaphorin receptor complex
Molecular Function:  protein binding; semaphorin receptor activity; signaling receptor binding
Biological Process:  cell adhesion; negative regulation of cell adhesion; positive regulation of axonogenesis; regulation of cell migration; regulation of cell shape; regulation of GTPase activity; regulation of synapse pruning; semaphorin-plexin signaling pathway involved in axon guidance
Reference #:  O60486 (UniProtKB)
Alt. Names/Synonyms: CD232; plexin (semaphorin receptor); plexin C1; Plexin-C1; PLXC1; PLXN-C1; PLXNC1; receptor for viral semaphorin protein; receptor for virally-encoded semaphorin; VESPR; Virus-encoded semaphorin protein receptor
Gene Symbols: PLXNC1
Molecular weight: 175,742 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein