KIFAP3 Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component:  axoneme; centrosome; ciliary basal body; ciliary tip; cilium; condensed nuclear chromosome; cytosol; endoplasmic reticulum; Golgi apparatus; kinesin II complex; microtubule cytoskeleton; periciliary membrane compartment; photoreceptor connecting cilium
Molecular Function:  intraciliary transport particle B binding; kinesin binding; protein binding; protein phosphatase binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; intraciliary transport involved in cilium assembly; microtubule-based movement; microtubule-based process; negative regulation of apoptotic process; negative regulation of cell proliferation; plus-end-directed vesicle transport along microtubule; positive regulation of calcium-dependent cell-cell adhesion; protein-containing complex assembly; retrograde vesicle-mediated transport, Golgi to ER; signal transduction
Reference #:  Q92845 (UniProtKB)
Alt. Names/Synonyms: dJ190I16.1; FLJ22818; KAP-3; KAP3; KIF3AP; KIFA3; KIFAP3; Kinesin-associated protein 3; small G protein GDP dissociation stimulator; SMAP; Smg GDS-associated protein; Smg-GDS
Gene Symbols: KIFAP3
Molecular weight: 91,205 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein