RNF213 iso5
E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity. Belongs to the AAA ATPase family. Widely expressed (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of human Ortholog: 17q25.3 |
Cellular Component:
cytoplasm; cytosol; lipid droplet; nucleolus
|
Molecular Function:
ATP binding; ATP hydrolysis activity; metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
|
Biological Process:
angiogenesis; defense response to bacterium; immune system process; lipid droplet formation; lipid ubiquitination; negative regulation of non-canonical Wnt signaling pathway; protein autoubiquitination; protein K63-linked ubiquitination; protein ubiquitination; regulation of lipid metabolic process; sprouting angiogenesis; ubiquitin-dependent protein catabolic process; xenophagy
|
Disease: Moyamoya Disease 2
|
Reference #:
Q63HN8-5
(UniProtKB)
|
Alt. Names/Synonyms: ALK lymphoma oligomerization partner on chromosome 17; ALO17; C17orf27; E3 ubiquitin-protein ligase RNF213; KIAA1554; KIAA1618; MYMY2; Mysterin; MYSTR; NET57; Protein ALO17; RING finger protein 213; RING-type E3 ubiquitin transferase RNF213; RN213; RNF213; RNF213 iso5
|
Gene Symbols: RNF213
|
Molecular weight:
118,436 Da
|
Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
|