RNF213 iso5 E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity. Belongs to the AAA ATPase family. Widely expressed (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  cytoplasm; cytosol; nucleolus
Molecular Function:  ATPase activity; metal ion binding; ubiquitin-protein transferase activity
Biological Process:  angiogenesis; negative regulation of non-canonical Wnt signaling pathway; protein autoubiquitination; protein homooligomerization; protein polyubiquitination; protein ubiquitination; sprouting angiogenesis; ubiquitin-dependent protein catabolic process
Disease: Moyamoya Disease 2
Reference #:  Q63HN8-5 (UniProtKB)
Alt. Names/Synonyms: ALK lymphoma oligomerization partner on chromosome 17; ALO17; E3 ubiquitin-protein ligase RNF213; KIAA1618; Protein ALO17; RNF213; RNF213 iso5
Gene Symbols: RNF213
Molecular weight: 118,436 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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RNF213 iso5

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene