ANKLE2 Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. Belongs to the ANKLE2 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 12q24.33
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function:  protein binding; protein phosphatase 2A binding; protein phosphatase regulator activity
Biological Process:  cell division; central nervous system development; mitotic nuclear membrane reassembly; negative regulation of apoptotic process; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; regulation of catalytic activity
Disease: Microcephaly 16, Primary, Autosomal Recessive
Reference #:  Q86XL3 (UniProtKB)
Alt. Names/Synonyms: ANKL2; ANKLE2; ankyrin repeat and LEM domain containing 2; Ankyrin repeat and LEM domain-containing protein 2; FLJ22280; FLJ36132; KIAA0692; LEM domain containing 7; LEM domain-containing protein 4; LEM4; LEMD7; MCPH16
Gene Symbols: ANKLE2
Molecular weight: 104,114 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein