ANKLE2
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. Belongs to the ANKLE2 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Protein phosphatase, regulatory subunit |
Chromosomal Location of human Ortholog: 12q24.33 |
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane
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Molecular Function:
protein binding; protein phosphatase 2A binding; protein phosphatase regulator activity
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Biological Process:
cell division; central nervous system development; mitotic nuclear membrane reassembly; negative regulation of apoptotic process; negative regulation of phosphorylation; positive regulation of protein dephosphorylation; regulation of catalytic activity
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Disease: Microcephaly 16, Primary, Autosomal Recessive
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Reference #:
Q86XL3
(UniProtKB)
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Alt. Names/Synonyms: ANKL2; ANKLE2; ankyrin repeat and LEM domain containing 2; Ankyrin repeat and LEM domain-containing protein 2; FLJ22280; FLJ36132; KIAA0692; LEM domain containing 7; LEM domain-containing protein 4; LEM4; LEMD7; MCPH16
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Gene Symbols: ANKLE2
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Molecular weight:
104,114 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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