CCDC79 Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. Belongs to the TERB1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear envelope
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  chromosome, telomeric region; nuclear chromosome, telomeric region; nuclear inner membrane
Molecular Function:  DNA binding
Biological Process:  meiotic attachment of telomere to nuclear envelope; meiotic telomere clustering; synapsis
Reference #:  Q8NA31 (UniProtKB)
Alt. Names/Synonyms: AC044802.1; CCD79; CCDC79; coiled-coil domain containing 79; Coiled-coil domain-containing protein 79; FLJ35894; telomere repeat binding bouquet formation protein 1; Telomere repeats-binding bouquet formation protein 1; TERB1
Gene Symbols: TERB1
Molecular weight: 83,064 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
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CCDC79

Protein Structure Not Found.


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