KDF1 Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  cell cortex; cell junction; cell leading edge; cytoplasm; mitotic spindle; nucleoplasm
Biological Process:  developmental growth; establishment of skin barrier; keratinocyte development; limb epidermis development; morphogenesis of embryonic epithelium; negative regulation of keratinocyte proliferation; negative regulation of stem cell proliferation; positive regulation of epidermal cell differentiation; regulation of epidermal cell division
Disease: Ectodermal Dysplasia 12, Hypohidrotic/hair/tooth/nail Type
Reference #:  Q8NAX2 (UniProtKB)
Alt. Names/Synonyms: C1orf172; CA172; ECTD12; FLJ34633; KDF1; Keratinocyte differentiation factor 1; RP11-344H11.3
Gene Symbols: KDF1
Molecular weight: 43,642 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene