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CARKD
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.2.1.93 |
| Chromosomal Location of mouse Ortholog: 8|8 A1.1 |
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Cellular Component:
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Molecular Function:
ATP binding; ATP-dependent NAD(P)H-hydrate dehydratase activity; hydro-lyase activity; lyase activity; nucleotide binding
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Biological Process:
metabolite repair
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Reference #:
Q9CZ42
(UniProtKB)
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Alt. Names/Synonyms: 0710008K08Rik; 2810407E01Rik; ATP-dependent (S)-NAD(P)H-hydrate dehydratase; ATP-dependent NAD(P)HX dehydratase; Car; carbohydrate kinase domain containing; Carbohydrate kinase domain-containing protein; Carkd; NAD(P)HX dehydratase; Naxd; NNRD
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Gene Symbols: Naxd
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Molecular weight:
36,717 Da
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Basal Isoelectric point:
7.67
Predict pI for various phosphorylation states
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