CARKD Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of Human Ortholog: 8|8 A1.1
Cellular Component:  cytosol; endoplasmic reticulum; mitochondrion
Molecular Function:  ADP-dependent NAD(P)H-hydrate dehydratase activity; ATP binding; ATP-dependent NAD(P)H-hydrate dehydratase activity; lyase activity; nucleotide binding
Reference #:  Q9CZ42 (UniProtKB)
Alt. Names/Synonyms: 0710008K08Rik; 2810407E01Rik; ATP-dependent (S)-NAD(P)H-hydrate dehydratase; ATP-dependent NAD(P)HX dehydratase; Car; carbohydrate kinase domain containing; Carbohydrate kinase domain-containing protein; Carkd; NAD(P)HX dehydratase; Naxd; NNRD
Gene Symbols: Carkd
Molecular weight: 36,717 Da
Basal Isoelectric point: 7.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene