ELG Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth. Belongs to the NCBP3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  cytoplasm; nuclear speck; nucleus; RNA cap binding complex
Molecular Function:  mRNA binding; protein binding; RNA 7-methylguanosine cap binding
Biological Process:  7-methylguanosine mRNA capping; defense response to virus; mRNA transport
Reference #:  Q53F19 (UniProtKB)
Alt. Names/Synonyms: C17orf85; ELG; ELG protein; HSA277841; NCBP3; Nuclear cap-binding protein subunit 3; Protein ELG
Gene Symbols: NCBP3
Molecular weight: 70,593 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein