DRP1 Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production. Isoform 1: Inhibits peroxisomal division when overexpressed. Isoform 4: Inhibits peroxisomal division when overexpressed. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component:  brush border; cell junction; clathrin-coated pit; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; presynaptic endocytic zone membrane; protein-containing complex; synaptic vesicle membrane
Molecular Function:  BH2 domain binding; clathrin binding; GTP binding; GTP-dependent protein binding; GTPase activator activity; GTPase activity; lipid binding; protein binding; protein homodimerization activity; protein-containing complex binding; Rab GTPase binding; ubiquitin protein ligase binding
Biological Process:  calcium ion transport; cellular response to oxygen-glucose deprivation; cellular response to thapsigargin; dynamin family protein polymerization involved in mitochondrial fission; execution phase of apoptosis; heart contraction; intracellular distribution of mitochondria; membrane fusion; mitochondrial fission; mitochondrial fragmentation involved in apoptotic process; mitochondrial membrane fission; mitochondrion morphogenesis; mitochondrion organization; necroptotic process; negative regulation of mitochondrial fusion; peroxisome fission; positive regulation of apoptotic process; positive regulation of dendritic spine morphogenesis; positive regulation of GTPase activity; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial fission; positive regulation of protein secretion; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle exocytosis; protein complex oligomerization; protein homotetramerization; protein localization to mitochondrion; regulation of ATP metabolic process; regulation of autophagy of mitochondrion; regulation of gene expression; regulation of mitochondrion organization; regulation of peroxisome organization; regulation of protein oligomerization; regulation of ubiquitin protein ligase activity; release of cytochrome c from mitochondria; response to flavonoid; response to hypobaric hypoxia; rhythmic process; synaptic vesicle endocytosis; synaptic vesicle recycling via endosome
Disease: Encephalopathy, Lethal, Due To Defective Mitochondrial And Peroxisomal Fission; Optic Atrophy 5
Reference #:  O00429 (UniProtKB)
Alt. Names/Synonyms: DLP1; DNM1L; Dnm1p/Vps1p-like protein; DRP1; DVLP; Dymple; dynamin 1 like; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV-11; EMPF; EMPF1; FLJ41912; HdynIV; OPA5; VPS1
Gene Symbols: DNM1L
Molecular weight: 81,877 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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