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cordon-bleu
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cell development/differentiation |
| Chromosomal Location of human Ortholog: 7p12.1 |
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Cellular Component:
actin filament; axon; axonal growth cone; cell cortex; dendrite; dendritic growth cone; membrane; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; ruffle; terminal web
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Molecular Function:
actin monomer binding; protein binding
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Biological Process:
actin filament network formation; actin filament polymerization; collateral sprouting in absence of injury; digestive tract development; embryonic axis specification; floor plate development; liver development; neural tube closure; notochord development; positive regulation of dendrite development; positive regulation of ruffle assembly; somite specification
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Reference #:
O75128
(UniProtKB)
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Alt. Names/Synonyms: COBL; cordon-bleu; cordon-bleu homolog (mouse); cordon-bleu WH2 repeat protein; DKFZp686G13227; KIAA0633; MGC131893; Protein cordon-bleu
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Gene Symbols: COBL
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Molecular weight:
135,617 Da
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Basal Isoelectric point:
7.66
Predict pI for various phosphorylation states
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