cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cell development/differentiation
Chromosomal Location of Human Ortholog: 7p12.1
Cellular Component:  axon; axonal growth cone; cell cortex; dendrite; dendritic growth cone; membrane; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; ruffle
Molecular Function:  actin monomer binding
Biological Process:  actin filament network formation; actin filament polymerization; collateral sprouting in absence of injury; digestive tract development; embryonic axis specification; floor plate development; liver development; neural tube closure; notochord development; positive regulation of dendrite development; positive regulation of ruffle assembly; somite specification
Reference #:  O75128 (UniProtKB)
Alt. Names/Synonyms: COBL; cordon-bleu; cordon-bleu homolog (mouse); cordon-bleu WH2 repeat protein; DKFZp686G13227; KIAA0633; MGC131893; Protein cordon-bleu
Gene Symbols: COBL
Molecular weight: 135,617 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB